HighCostDrugsDemo/CLAUDE.md

CLAUDE.md

This file provides guidance to Claude Code (claude.ai/code) when working with code in this repository.

Project Overview

NHS High-Cost Drug Patient Pathway Analysis Tool - a web-based application that analyzes secondary care patient treatment pathways. It processes clinical activity data to visualize hierarchical treatment patterns as interactive Plotly icicle charts.

Key Features:

• Dual chart types: Directory-based (Trust → Directory → Drug → Pathway) and Indication-based (Trust → GP Diagnosis → Drug → Pathway) views with toggle
• Pre-computed pathway architecture: Treatment pathways pre-processed and stored in SQLite for instant filtering
• GP diagnosis matching: Patient indications matched from GP records using SNOMED cluster codes queried directly from Snowflake (~93% match rate)
• Data pipeline: Snowflake → pre-computed SQLite pathway nodes (CSV/Parquet file loading retained for legacy compatibility)
• Interactive browser-based UI using Dash (Plotly) + Dash Mantine Components
• 6 pre-defined date filter combinations × 2 chart types = 12 pre-computed datasets with sub-50ms response times

Running the Application

# Install dependencies
uv sync

# One-time dev setup: adds src/ to Python path via .pth file
uv run python setup_dev.py

# Initialize/migrate the database (creates pathway tables)
python -m data_processing.migrate

# Refresh pathway data from Snowflake (requires SSO auth)
python -m cli.refresh_pathways

# Run the Dash web application
python run_dash.py

The application requires Python 3.10+ and runs on http://localhost:8050 by default.

CLI Commands

Refresh Pathway Data:

# Full refresh — both chart types (directory + indication), all date filters
python -m cli.refresh_pathways --chart-type all

# Directory charts only (faster, skips GP diagnosis lookup)
python -m cli.refresh_pathways --chart-type directory

# Indication charts only
python -m cli.refresh_pathways --chart-type indication

# Dry run (test without database changes)
python -m cli.refresh_pathways --chart-type all --dry-run -v

# Custom minimum patient threshold
python -m cli.refresh_pathways --minimum-patients 10

# Help
python -m cli.refresh_pathways --help

The --chart-type argument controls which pathway types are processed:

• all (default) — generates both directory and indication charts (~15 minutes)
• directory — directory-based charts only (~5 minutes)
• indication — indication-based charts only (~12 minutes, includes GP lookup)

The refresh command:

1. Fetches activity data from Snowflake (656K+ records, ~7 seconds)
2. Applies UPID, drug name, and directory transformations (~6 minutes)
3. For indication charts: queries GP records via SNOMED clusters (~9 minutes for 37K patients)
4. Processes 6 date filter combinations × selected chart types
5. Inserts pathway nodes to SQLite for fast Dash filtering

Architecture

Package Structure

.
├── src/                         # All application library code
│   ├── core/                    # Foundation: paths, models, logging
│   │   ├── config.py           # PathConfig dataclass for file paths
│   │   ├── models.py           # AnalysisFilters dataclass
│   │   └── logging_config.py   # Structured logging setup
│   │
│   ├── config/                  # Service configuration
│   │   ├── __init__.py         # SnowflakeConfig + loader
│   │   └── snowflake.toml      # Connection settings (co-located with loader)
│   │
│   ├── data_processing/         # Data layer
│   │   ├── database.py         # SQLite connection management
│   │   ├── schema.py           # Database schema (reference + pathway tables)
│   │   ├── pathway_pipeline.py # Pipeline: Snowflake → SQLite
│   │   ├── transforms.py       # Data transformations (UPID, drug names, directory)
│   │   ├── loader.py           # FileDataLoader for CSV/Parquet files
│   │   ├── reference_data.py   # Reference data migration
│   │   ├── snowflake_connector.py  # Snowflake integration
│   │   ├── cache.py            # Query result caching
│   │   ├── data_source.py      # Data source fallback chain
│   │   └── diagnosis_lookup.py # GP diagnosis lookup (SNOMED clusters)
│   │
│   ├── analysis/                # Analysis pipeline
│   │   ├── pathway_analyzer.py # prepare_data, calculate_statistics, build_hierarchy
│   │   └── statistics.py       # Statistical calculation functions
│   │
│   ├── visualization/           # Chart generation
│   │   └── plotly_generator.py # create_icicle_figure, create_icicle_from_nodes
│   │
│   └── cli/                     # CLI tools
│       └── refresh_pathways.py # Data refresh command
│
├── dash_app/                    # Dash web application
│   ├── app.py                  # Dash app, layout root, dcc.Store, register_callbacks
│   ├── assets/
│   │   └── nhs.css             # NHS design system CSS (from 01_nhs_classic.html)
│   ├── data/
│   │   ├── queries.py          # Thin wrapper calling src/data_processing/pathway_queries.py
│   │   └── card_browser.py     # DimSearchTerm.csv → directorate tree for drawer
│   ├── components/
│   │   ├── header.py           # Top header bar with data freshness indicator
│   │   ├── sidebar.py          # Left navigation with drawer triggers
│   │   ├── kpi_row.py          # 4 KPI cards (patients, drugs, cost, match rate)
│   │   ├── filter_bar.py       # Chart type toggle pills + date filter dropdowns
│   │   ├── chart_card.py       # Chart area with tabs + dcc.Graph + loading spinner
│   │   ├── drawer.py           # dmc.Drawer with drug/trust chips + directorate cards
│   │   └── footer.py           # Page footer
│   ├── callbacks/
│   │   ├── __init__.py         # register_callbacks(app)
│   │   ├── filters.py          # Reference data loading + filter state management
│   │   ├── chart.py            # Pathway data loading + icicle chart rendering
│   │   ├── drawer.py           # Drawer open/close + drug/trust selection
│   │   └── kpi.py              # KPI card value updates
│   └── utils/
│       └── __init__.py
│
├── run_dash.py                  # Entry point: python run_dash.py
├── tests/                       # Test suite (113 tests)
├── data/                        # Reference data + SQLite DB
├── docs/                        # Documentation
├── assets/                      # Static assets (logo, favicon)
├── archive/                     # Historical/deprecated (includes old Reflex app)
└── logs/                        # Runtime logs

Path resolution: src/ is added to sys.path via a .pth file (created by setup_dev.py). All imports use package names directly: from core import ..., from data_processing import ..., etc.

Pathway Data Architecture

The application uses a pre-computed pathway architecture for performance:

Architecture: Snowflake → Pathway Processing → SQLite (pre-computed) → Dash (filter & view)

Key Benefits:

• Performance: Pathway calculation done once during data refresh, not on every filter change
• Simplicity: Dash callbacks filter pre-computed data with simple SQL WHERE clauses
• Full Pathways: Sequential treatment pathways (drug_0 → drug_1 → drug_2...) with statistics

Chart Types:

Type	Hierarchy	Level 2 Source
directory	Trust → Directory → Drug → Pathway	Assigned directorate (5-level fallback)
indication	Trust → GP Diagnosis → Drug → Pathway	SNOMED cluster Search_Term from GP records

For indication charts, ~93% of patients are matched to a GP diagnosis (Search_Term). Unmatched patients use their directorate as a fallback label (e.g., "RHEUMATOLOGY (no GP dx)").

Date Filter Combinations:

ID	Initiated	Last Seen	Default
all_6mo	All years	Last 6 months	Yes
all_12mo	All years	Last 12 months	No
1yr_6mo	Last 1 year	Last 6 months	No
1yr_12mo	Last 1 year	Last 12 months	No
2yr_6mo	Last 2 years	Last 6 months	No
2yr_12mo	Last 2 years	Last 12 months	No

Total pre-computed datasets: 6 date filters × 2 chart types = 12 datasets (~3,600 pathway nodes).

Pathway Node Structure: Each node in pathway_nodes contains:

• Routing: chart_type ("directory" or "indication"), date_filter_id
• Hierarchy: parents, ids, labels, level (0=Root, 1=Trust, 2=Directory/Indication, 3=Drug, 4+=Pathway)
• Counts: value (patient count)
• Costs: cost, costpp, cost_pp_pa (per patient per annum)
• Dates: first_seen, last_seen, first_seen_parent, last_seen_parent
• Statistics: average_spacing, average_administered, avg_days
• Denormalized: trust_name, directory, drug_sequence (for efficient filtering)
• Unique constraint: UNIQUE(date_filter_id, chart_type, ids)

Core Module (core/)

• PathConfig - Dataclass encapsulating all file paths, with validate() method
• AnalysisFilters - Dataclass for filter state (dates, drugs, trusts, directories)
• logging_config - Structured logging with file and console output

CLI Module (cli/)

• refresh_pathways.py - Command-line tool to refresh pre-computed pathway data:
  • refresh_pathways() - Main function orchestrating the full pipeline
  • insert_pathway_records() - SQLite insertion with parameterized queries
  • log_refresh_start/complete/failed() - Refresh tracking in pathway_refresh_log
  • get_default_filters() - Load trusts/drugs/directories from CSV files

Data Processing Module (data_processing/)

Database Management:

• DatabaseManager - SQLite connection pooling and transaction management
• Reference Tables: ref_drug_names, ref_organizations, ref_directories, ref_drug_directory_map, ref_drug_indication_clusters
• Pathway Tables: pathway_date_filters, pathway_nodes, pathway_refresh_log

Pathway Pipeline (pathway_pipeline.py):

• DateFilterConfig - Dataclass for date filter configuration
• DATE_FILTER_CONFIGS - All 6 pre-defined date combinations
• compute_date_ranges(config, max_date) - Computes actual ISO dates from config
• fetch_and_transform_data() - Snowflake fetch + UPID/drug/directory transformations
• Directory chart functions:
  • process_pathway_for_date_filter() - Processes single date filter using generate_icicle_chart()
  • extract_denormalized_fields() - Parses ids column to extract trust, directory, drug_sequence
• Indication chart functions:
  • process_indication_pathway_for_date_filter() - Processes single date filter using generate_icicle_chart_indication()
  • extract_indication_fields() - Parses ids for indication charts (trust, search_term, drug_sequence)
• Shared functions:
  • convert_to_records(ice_df, chart_type) - Converts ice_df to list of dicts with chart_type column
  • process_all_date_filters() - Convenience function to process all 6 filters

Data Loaders:

• FileDataLoader - Loads from CSV/Parquet files (used by legacy pipeline, not by Dash app)
• Factory function get_loader() creates a FileDataLoader

Snowflake Integration:

• SSO authentication via externalbrowser authenticator
• fetch_activity_data(start_date, end_date, provider_codes) method
• Query caching with TTL-based invalidation

GP Diagnosis Lookup (diagnosis_lookup.py):

• CLUSTER_MAPPING_SQL - Embedded SQL constant with ~148 Search_Term → Cluster_ID mappings plus explicit SNOMED codes
• get_patient_indication_groups(patient_pseudonyms) - Batch queries Snowflake to match patients to GP diagnoses:
  • Embeds cluster mapping as CTE, joins with PrimaryCareClinicalCoding
  • Uses PseudoNHSNoLinked (not PersonKey) to match PatientPseudonym in GP records
  • Returns most recent match per patient via QUALIFY ROW_NUMBER()
  • Batches 500 patients per query, returns DataFrame with PatientPseudonym, Search_Term, EventDateTime
• patient_has_indication(patient_pseudonym, cluster_ids) - Single-patient GP record check (legacy)
• validate_indication(patient_pseudonym, drug_name) - Full validation result with source tracking (legacy)

Analysis Module (analysis/)

Refactored from the original 267-line generate_graph() function:

• prepare_data() - Filter DataFrame by date range, trusts, drugs, directories (copies df to prevent mutation)
• calculate_statistics() - Compute frequency, cost, duration statistics
• build_hierarchy() - Create Trust → Directory → Drug → Pathway structure
• prepare_chart_data() - Format data for Plotly icicle chart
• generate_icicle_chart_indication(df, indication_df, ...) - Build indication-based hierarchy using Search_Term instead of Directory. Takes an indication_df (UPID → Search_Term mapping) alongside the main activity DataFrame.

Visualization Module (visualization/)

• create_icicle_figure(ice_df) - Generate Plotly icicle chart from DataFrame (legacy/pipeline use)
• create_icicle_from_nodes(nodes, title) - Generate icicle chart from list-of-dicts (Dash use). Accepts JSON-serializable node dicts from dcc.Store. Uses NHS blue gradient colorscale, 10-field customdata, Source Sans 3 font.
• save_figure_html() - Save interactive HTML file
• open_figure_in_browser() - Open chart in default browser

Shared Data Queries (data_processing/pathway_queries.py)

Shared query functions used by both the Dash app and potentially other consumers:

• load_initial_data(db_path) - Returns available drugs (42), directorates (14), indications (32), trusts (7), total_patients, last_updated
• load_pathway_nodes(db_path, filter_id, chart_type, selected_drugs, selected_directorates, selected_trusts) - Returns pathway nodes, unique_patients, total_drugs, total_cost, last_updated. Parameterized SQL with optional drug/directorate/trust filters.

Dash Application (dash_app/)

State Management via 3 dcc.Store components:

• app-state (session): chart_type, initiated, last_seen, date_filter_id, selected_drugs, selected_directorates, selected_trusts
• chart-data (memory): nodes[], unique_patients, total_drugs, total_cost, last_updated
• reference-data (session): available_drugs, available_directorates, available_indications, available_trusts, total_patients, last_updated

Callback Chain (unidirectional):

Page Load → load_reference_data → reference-data store + header indicators
         → update_app_state → app-state store (default filters)
                             → load_pathway_data → chart-data store
                                                  ├→ update_kpis → KPI cards
                                                  └→ update_chart → dcc.Graph

Filter change → update_app_state → app-state → load_pathway_data → (chain above)
Drawer selection → all-drugs-chips/trust-chips → update_app_state → (chain above)

Key Components:

• Header (header.py): NHS branding, data freshness indicator (patient count + relative time)
• Sidebar (sidebar.py): Navigation items with drawer trigger IDs for Drug Selection, Trust Selection, Indications
• Filter Bar (filter_bar.py): Chart type toggle pills (By Directory / By Indication) + date filter dropdowns
• KPI Row (kpi_row.py): 4 cards — Unique Patients, Drug Types, Total Cost, Indication Match Rate (~93%)
• Chart Card (chart_card.py): Icicle chart with dcc.Loading spinner, dynamic subtitle, tab row
• Drawer (drawer.py): dmc.Drawer with drug chips (dmc.ChipGroup), trust chips, directorate accordion with indication sub-items and drug fragment badges
• Footer (footer.py): NHS Norfolk and Waveney ICB branding

Drawer Drug Browser:

• "All Drugs" section: flat dmc.ChipGroup with 42 drugs from pathway_nodes level 3
• "Trusts" section: dmc.ChipGroup with 7 trusts
• "By Directorate" section: nested dmc.Accordion — 19 directorates → indications → drug fragment dmc.Badge items
• Clicking a drug fragment badge selects all full drug names containing that fragment (substring match)
• "Clear All Filters" button resets drug and trust selections

Data Transformations (data_processing/transforms.py)

Core data transformation functions used by the pipeline:

• patient_id() - Creates UPID = Provider Code (first 3 chars) + PersonKey
• drug_names() - Standardizes via drugnames.csv lookup
• department_identification() - 5-level fallback chain for directory assignment

Data Flow

Pre-Computed Pathway Architecture (Current):

[CLI: python -m cli.refresh_pathways --chart-type all]

    Snowflake Data Warehouse
           │
           ▼ (fetch_and_transform_data)
    ┌──────────────────────────────────────────┐
    │ Data Transformations (data_processing/transforms.py)     │
    │   → patient_id() creates UPID            │
    │   → drug_names() standardizes names      │
    │   → department_identification() → Dir    │
    └──────────────────────────────────────────┘
           │
           ├─── Directory Charts ──────────────────────────────────────┐
           │                                                           │
           │    ┌──────────────────────────────────────────┐           │
           │    │ For each of 6 date filter combos:        │           │
           │    │   → generate_icicle_chart()              │           │
           │    │   → extract_denormalized_fields()        │           │
           │    │   → convert_to_records("directory")      │           │
           │    └──────────────────────────────────────────┘           │
           │                                                           │
           ├─── Indication Charts ─────────────────────────────────────┤
           │                                                           │
           │    ┌──────────────────────────────────────────┐           │
           │    │ GP Diagnosis Lookup (diagnosis_lookup.py)│           │
           │    │   → Extract PseudoNHSNoLinked from HCD   │           │
           │    │   → get_patient_indication_groups()      │           │
           │    │     (SNOMED cluster CTE + GP records)    │           │
           │    │   → Build indication_df: UPID → Search   │           │
           │    │     Term (matched) or Directorate (no GP)│           │
           │    └──────────────────────────────────────────┘           │
           │                        │                                  │
           │                        ▼                                  │
           │    ┌──────────────────────────────────────────┐           │
           │    │ For each of 6 date filter combos:        │           │
           │    │   → generate_icicle_chart_indication()   │           │
           │    │   → extract_indication_fields()          │           │
           │    │   → convert_to_records("indication")     │           │
           │    └──────────────────────────────────────────┘           │
           │                                                           │
           └───────────────────────┬───────────────────────────────────┘
                                   │
                                   ▼ (insert_pathway_records)
    ┌──────────────────────────────────────────┐
    │ SQLite: pathway_nodes table              │
    │   → ~3,600 nodes across 12 datasets      │
    │   → UNIQUE(date_filter_id, chart_type,   │
    │     ids) prevents cross-type overwrites  │
    │   → Indexed for fast filtering           │
    └──────────────────────────────────────────┘


[Dash App: python run_dash.py]

    ┌──────────────────────────────────────────┐
    │ Filter Bar + Drawer (toggle pills,       │
    │   date dropdowns, drug/trust chips)      │
    │   → Triggers update_app_state callback   │
    └──────────────────────────────────────────┘
           │
           ▼
    ┌──────────────────────────────────────────┐
    │ load_pathway_data callback               │
    │   → Input: app-state dcc.Store           │
    │   → Calls pathway_queries.load_pathway_  │
    │     nodes() with filters                 │
    │   → Output: chart-data dcc.Store         │
    └──────────────────────────────────────────┘
           │
           ├──────────────────────────────┐
           ▼                              ▼
    ┌────────────────────┐  ┌──────────────────────┐
    │ update_kpis        │  │ update_chart         │
    │   → 4 KPI cards    │  │   → create_icicle_   │
    │   → formatted      │  │     from_nodes()     │
    │     counts/costs   │  │   → 10-field custom- │
    └────────────────────┘  │     data + NHS blue  │
                            │   → dcc.Graph figure │
                            └──────────────────────┘

Reference Data Files (data/)

File	Purpose
include.csv	Drug filter list with default selections (Include=1)
defaultTrusts.csv	NHS Trust list for filter
directory_list.csv	Medical specialties/directories
drugnames.csv	Drug name standardization mapping
org_codes.csv	Provider code to organization name mapping
drug_directory_list.csv	Valid drug-to-directory mappings (pipe-separated)
treatment_function_codes.csv	NHS treatment function code mappings
drug_indication_clusters.csv	Drug to SNOMED cluster mappings
ta-recommendations.xlsx	NICE TA recommendations
pathways.db	SQLite database (~3.5 MB: reference tables + pathway nodes)

Key Patterns

Department Identification Fallback Chain: The department_identification() function has 5 levels of fallback:

1. SINGLE_VALID_DIR - Drug has only one valid directory
2. EXTRACTED - Extracted from Additional Detail/Description fields
3. CALCULATED_MOST_FREQ - Most frequent valid directory for UPID/Drug
4. UPID_INFERENCE - Inferred from other records with same UPID
5. UNDEFINED - No directory could be determined

Indication Lookup Workflow (for indication charts):

1. Extract unique PseudoNHSNoLinked values from HCD activity data
2. Query Snowflake in batches of 500 patients:
   • Embed CLUSTER_MAPPING_SQL (~148 Search_Term → Cluster_ID mappings) as CTE
   • Join ClinicalCodingClusterSnomedCodes to get SNOMED codes per cluster
   • Join PrimaryCareClinicalCoding on PatientPseudonym = PseudoNHSNoLinked
   • Use QUALIFY ROW_NUMBER() OVER (PARTITION BY PatientPseudonym ORDER BY EventDateTime DESC) = 1 for most recent match
3. Build indication_df mapping UPID → Search_Term (matched) or Directorate + " (no GP dx)" (unmatched)
4. Pass to generate_icicle_chart_indication() for pathway hierarchy building

Data Source Fallback Chain (for raw data loading, not used by Dash app):

1. Query cache for recent results
2. Attempt Snowflake connection
3. Fall back to CSV/Parquet files

Database Schema (~3.5 MB)

Reference Tables

• ref_drug_names - Drug name standardization
• ref_organizations - Provider code to name mapping
• ref_directories - Valid directory names
• ref_drug_directory_map - Valid drug-directory pairs
• ref_drug_indication_clusters - Drug to SNOMED cluster mapping

Pathway Tables

• pathway_date_filters - 6 pre-defined date filter combinations
  • Columns: id, initiated, last_seen, is_default, description
  • Auto-populated via migration
• pathway_nodes - Pre-computed pathway hierarchy nodes (~3,600 rows for 12 datasets)
  • Routing: chart_type ("directory" or "indication"), date_filter_id
  • Hierarchy: parents, ids, labels, level
  • Metrics: value, cost, costpp, cost_pp_pa, colour
  • Dates: first_seen, last_seen, first_seen_parent, last_seen_parent
  • Statistics: average_spacing, average_administered, avg_days
  • Denormalized: trust_name, directory, drug_sequence
  • Foreign key: date_filter_id → pathway_date_filters.id
  • Unique constraint: UNIQUE(date_filter_id, chart_type, ids) — critical for INSERT OR REPLACE correctness
  • Indexed for: date_filter_id, chart_type, trust_name, directory, level
• pathway_refresh_log - Tracks data refresh status
  • Columns: refresh_id, started_at, completed_at, status, records_processed, error_message, source_row_count

Input Data Requirements

The input data (CSV/Parquet) must contain columns including:

• Provider Code, PersonKey - Used to create UPID
• PseudoNHSNoLinked - NHS pseudonym for GP record matching (indication charts)
• Drug Name, Intervention Date, Price Actual
• OrganisationName
• Various Additional Detail/Description columns for directory extraction
• Treatment Function Code

Output

Interactive Plotly icicle chart with toggleable views:

• Directory view: Trust → Directorate → Drug → Patient Pathway
• Indication view: Trust → GP Diagnosis (Search_Term) → Drug → Patient Pathway
• Patient counts and percentages at each hierarchy level
• Total and average costs
• Treatment duration and dosing frequency information
• Color gradient based on patient volume

Testing

# Run all tests with coverage
python -m pytest tests/ -v --cov=core --cov=analysis

# Run specific test file
python -m pytest tests/test_config.py -v

# Run specific test class
python -m pytest tests/test_data_transformations.py::TestPatientId -v

Test coverage includes:

• PathConfig validation (23 tests)
• AnalysisFilters validation (26 tests)
• Data transformation functions (23 tests)
• Directory assignment logic (19 tests)

Configuration

Snowflake Connection (src/config/snowflake.toml)

[snowflake]
account = "your-account"
database = "DATA_HUB"
schema = "CDM"
warehouse = "your-warehouse"
authenticator = "externalbrowser"  # Required for NHS SSO

Logging

Logs are written to logs/ directory with structured format. Configure via src/core/logging_config.py.

Breaking Changes from Original App

The pre-computed pathway architecture introduces these changes:

Date Filters

• Old: Date pickers for arbitrary start_date and end_date
• New: Two dropdowns:
  • "Treatment Initiated": All years, Last 2 years, Last 1 year
  • "Last Seen": Last 6 months, Last 12 months
• Reason: Pre-computed pathways require fixed date combinations for performance

Data Refresh

• Old: Real-time pathway calculation on each filter change
• New: Pre-computed pathways stored in SQLite, refreshed via CLI command
• Impact: Data is as fresh as the last python -m cli.refresh_pathways run
• Benefit: Sub-50ms filter response time vs multi-minute calculations

State Management (Dash)

• State lives in 3 dcc.Store components: app-state, chart-data, reference-data
• Filter state: chart_type, initiated, last_seen, date_filter_id, selected_drugs, selected_directorates, selected_trusts
• Chart type toggle: "By Directory" / "By Indication" pills in filter bar
• Dynamic subtitle: "Trust → Directorate → Drug → Pathway" or "Trust → Indication → Drug → Pathway"
• Drug/trust selection via dmc.ChipGroup in right-side drawer

Icicle Chart

• Full 10-field customdata structure (value, colour, cost, costpp, first_seen, last_seen, first_seen_parent, last_seen_parent, average_spacing, cost_pp_pa)
• NHS blue gradient colorscale: Heritage Blue #003087 → Pale Blue #E3F2FD
• Treatment statistics (average_spacing, cost_pp_pa) in hover tooltips
• First/last seen dates for drug nodes
• create_icicle_from_nodes() in src/visualization/plotly_generator.py — shared function accepting list-of-dicts

Development

Adding New Analysis Features

1. Add statistical functions to src/analysis/statistics.py
2. Integrate into pipeline in src/analysis/pathway_analyzer.py
3. Update visualization in src/visualization/plotly_generator.py

Adding New Reference Data

1. Add CSV file to data/ directory
2. Define schema in src/data_processing/schema.py
3. Create migration function in src/data_processing/reference_data.py
4. Add path to PathConfig in src/core/config.py