HighCostDrugsDemo/data/DimSearchTerm.csv at main

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Andrew Charlwood a31907aa1f feat: complete drug-aware indication matching and cleanup app_v2

- Remove app_v2.py (consolidated into pathways_app.py), fix __init__ import
- Add DimSearchTerm.csv, drug_indication_clusters.csv, drug_snomed_mapping_enriched.csv
  as reference data for SNOMED-based indication matching
- Add snomed_indication_mapping_query.sql (source for embedded cluster mapping)
- Update DESIGN_SYSTEM.md, RALPH_PROMPT.md, ralph.ps1, uv.lock

2026-02-06 00:33:29 +00:00

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1	Search_Term	CleanedDrugName	PrimaryDirectorate
2	acute coronary syndrome	ABCIXIMAB\|CLOPIDOGREL\|PRASUGREL\|RIVAROXABAN\|TICAGRELOR	CARDIOLOGY
3	acute lymphoblastic leukaemia	BLINATUMOMAB\|DASATINIB\|INOTUZUMAB\|PEGASPARGASE\|PONATINIB\|TISAGENLECLEUCEL	CLINICAL HAEMATOLOGY
4	acute myeloid leukaemia	AZACITIDINE\|DECITABINE\|GEMTUZUMAB\|GILTERITINIB\|GLASDEGIB\|LIPOSOMAL\|MIDOSTAURIN\|ORAL\|VENETOCLAX	CLINICAL HAEMATOLOGY
5	acute promyelocytic leukaemia	ARSENIC\|GEMTUZUMAB	CLINICAL HAEMATOLOGY
6	allergic asthma	OMALIZUMAB	THORACIC MEDICINE
7	allergic rhinitis	SQ	ENT
8	alzheimer's disease	DONEPEZIL	NEUROLOGY
9	amyloidosis	VUTRISIRAN	CLINICAL HAEMATOLOGY
10	anaemia	ERYTHROPOIESIS-STIMULATING\|ERYTHROPOIETIN	CLINICAL HAEMATOLOGY
11	anaplastic large cell lymphoma	BRENTUXIMAB	CLINICAL HAEMATOLOGY
12	ankylosing spondylitis	ADALIMUMAB\|GOLIMUMAB\|SECUKINUMAB\|UPADACITINIB	RHEUMATOLOGY
13	apixaban	ANDEXANET	CARDIOLOGY
14	aplastic anaemia	ELTROMBOPAG	CLINICAL HAEMATOLOGY
15	arthritis	ETANERCEPT	RHEUMATOLOGY
16	asthma	BENRALIZUMAB\|DUPILUMAB\|INHALED\|MEPOLIZUMAB\|OMALIZUMAB\|RESLIZUMAB	THORACIC MEDICINE
17	atopic dermatitis	ABROCITINIB\|ALCLOMETASONE\|BARICITINIB\|CRISABOROLE\|DUPILUMAB\|PIMECROLIMUS	DERMATOLOGY
18	atrial fibrillation	APIXABAN\|DABIGATRAN\|DRONEDARONE\|EDOXABAN\|RIVAROXABAN\|VERNAKALANT	CARDIOLOGY
19	attention deficit hyperactivity disorder	ATOMOXETINE	MENTAL HEALTH
20	attention-deficit hyperactivity disorder	METHYLPHENIDATE	MENTAL HEALTH
21	axial spondyloarthritis	ADALIMUMAB\|GOLIMUMAB\|IXEKIZUMAB\|SECUKINUMAB\|UPADACITINIB	RHEUMATOLOGY
22	basal cell carcinoma	VISMODEGIB	DERMATOLOGY
23	bipolar disorder	LOXAPINE\|OLANZAPINE	MENTAL HEALTH
24	bladder	MIRABEGRON	MEDICAL ONCOLOGY
25	brca	OLAPARIB	MEDICAL ONCOLOGY
26	breast cancer	ABEMACICLIB\|ALPELISIB\|ANASTROZOLE\|ATEZOLIZUMAB\|BEVACIZUMAB\|CAPECITABINE\|DENOSUMAB\|DOCETAXEL\|ERIBULIN\|EVEROLIMUS\|FULVESTRANT\|GEMCITABINE\|INTRABEAM\|LAPATINIB\|NERATINIB\|OLAPARIB\|PACLITAXEL\|PALBOCICLI\|PALBOCICLIB\|PEMBROLIZUMAB\|PERTUZUMAB\|RIBOCICLIB\|SACITUZUMAB\|TRASTUZUMAB\|TUCATINIB\|VINORELBINE	MEDICAL ONCOLOGY
27	cardiomyopathy	TAFAMIDIS	CARDIOLOGY
28	cardiovascular disease	ATORVASTATIN	CARDIOLOGY
29	cervical cancer	TOPOTECAN	MEDICAL ONCOLOGY
30	cholangiocarcinoma	PEMIGATINIB	MEDICAL ONCOLOGY
31	choroidal neovascularisation	AFLIBERCEPT\|RANIBIZUMAB	OPHTHALMOLOGY
32	chronic kidney disease	DAPAGLIFLOZIN\|IMLIFIDASE\|ROXADUSTAT	NEPHROLOGY
33	chronic liver disease	AVATROMBOPAG\|LUSUTROMBOPAG	GASTROENTEROLOGY
34	chronic lymphocytic leukaemia	ACALABRUTINIB\|BENDAMUSTINE\|DUVELISIB\|IBRUTINIB\|IDELALISIB\|OBINUTUZUMAB\|OFATUMUMAB\|RITUXIMAB\|VENETOCLAX	CLINICAL HAEMATOLOGY
35	chronic myeloid leukaemia	ASCIMINIB\|BOSUTINIB\|STANDARD-DOSE\|DASATINIB\|DASITINIB\|NILOTINIB\|PONATINIB	CLINICAL HAEMATOLOGY
36	chronic obstructive pulmonary disease	ROFLUMILAST	THORACIC MEDICINE
37	colon cancer	CAPECITABINE	MEDICAL ONCOLOGY
38	colorectal cancer	BEVACIZUMAB\|CAPECITABINE\|IRINOTECAN	MEDICAL ONCOLOGY
39	constipation	LUBIPROSTONE\|METHYLNALTREXONE\|NALDEMEDINE\|NALOXEGOL\|PRUCALOPRIDE	GASTROENTEROLOGY
40	covid-19	NIRMATRELVIR	INFECTIOUS DISEASES
41	crohn's disease	INFLIXIMAB\|VEDOLIZUMAB	GASTROENTEROLOGY
42	cutaneous t-cell lymphoma	BRENTUXIMAB\|CHLORMETHINE	CLINICAL HAEMATOLOGY
43	cystic fibrosis	COLISTIMETHATE\|LUMACAFTOR\|MANNITOL	THORACIC MEDICINE
44	cytomegalovirus	LETERMOVIR\|MARIBAVIR	INFECTIOUS DISEASES
45	deep vein thrombosis	APIXABAN\|DABIGATRAN\|EDOXABAN\|RIVAROXABAN	VASCULAR SURGERY
46	depression	ESKETAMINE	MENTAL HEALTH
47	diabetes	ERTUGLIFLOZIN\|INHALED\|AFLIBERCEPT\|BROLUCIZUMAB\|DEXAMETHASONE\|FARICIMAB\|FLUOCINOLONE\|RANIBIZUMAB	DIABETIC MEDICINE
48	diabetes	ERTUGLIFLOZIN\|INHALED\|AFLIBERCEPT\|BROLUCIZUMAB\|DEXAMETHASONE\|FARICIMAB\|FLUOCINOLONE\|RANIBIZUMAB	OPHTHALMOLOGY
49	diabetic retinopathy	RANIBUZIMAB	OPHTHALMOLOGY
50	diffuse large b-cell lymphoma	AXICABTAGENE\|POLATUZUMAB\|TISAGENLECLEUCEL	CLINICAL HAEMATOLOGY
51	dravet syndrome	CANNABIDIOL\|FENFLURAMINE	NEUROLOGY
52	drug misuse	BUPRENORPHINE\|NALTREXONE	MENTAL HEALTH
53	dry eye	CICLOSPORIN	OPHTHALMOLOGY
54	dyspepsia	LANSOPRAZOLE	GASTROENTEROLOGY
55	endometrial cancer	DOSTARLIMAB	MEDICAL ONCOLOGY
56	epilepsy	CENOBAMATE\|GABAPENTIN\|RETIGABINE	NEUROLOGY
57	fallopian tube	BEVACIZUMAB\|NIRAPARIB\|OLAPARIB\|RUCAPARIB	MEDICAL ONCOLOGY
58	follicular lymphoma	DUVELISIB\|IDELALISIB\|LENALIDOMIDE\|OBINUTUZUMAB\|RITUXIMAB\|TISAGENLECLEUCEL	CLINICAL HAEMATOLOGY
59	gastric cancer	CAPECITABINE\|RAMUCIRUMAB\|TRASTUZUMAB\|TRIFLURIDINE	MEDICAL ONCOLOGY
60	gastro-oesophageal junction	NIVOLUMAB\|PEMBROLIZUMAB	MEDICAL ONCOLOGY
61	giant cell arteritis	TOCILIZUMAB	RHEUMATOLOGY
62	glioma	CARMUSTINE	MEDICAL ONCOLOGY
63	gout	CANAKINUMAB\|FEBUXOSTAT\|LESINURAD	RHEUMATOLOGY
64	graft versus host disease	RUXOLITINIB	CLINICAL HAEMATOLOGY
65	granulomatosis with polyangiitis	AVACOPAN\|MEPOLIZUMAB	RHEUMATOLOGY
66	growth hormone deficiency	SOMATROPIN	ENDOCRINOLOGY
67	hand eczema	ALITRETINOIN	DERMATOLOGY
68	heart failure	DAPAGLIFLOZIN\|EMPAGLIFLOZIN\|IVABRADINE\|SACUBITRIL\|VERICIGUAT	CARDIOLOGY
69	hepatitis b	ADEFOVIR	GASTROENTEROLOGY
70	hepatitis c	BOCEPREVIR\|DACLATASVIR\|ELBASVIR\|GLECAPREVIR\|INTERFERON\|LEDIPASVIR\|OMBITASVIR\|PEGINTERFERON\|PEGYLATED\|SIMEPREVIR\|SOFOSBUVIR\|TELAPREVIR	GASTROENTEROLOGY
71	hepatocellular carcinoma	ATEZOLIZUMAB\|CABOZANTINIB\|LENVATINIB\|RAMUCIRUMAB\|REGORAFENIB\|SELECTIVE\|SORAFENIB	MEDICAL ONCOLOGY
72	hiv	CABOTEGRAVIR	INFECTIOUS DISEASES
73	hodgkin lymphoma	BRENTUXIMAB\|NIVOLUMAB\|PEMBROLIZUMAB	CLINICAL HAEMATOLOGY
74	hormone receptor	ABEMACICLIB	MEDICAL ONCOLOGY
75	hypercholesterolaemia	EZETIMIBE	CARDIOLOGY
76	hyperparathyroidism	CINACALCET\|ETELCALCETIDE	ENDOCRINOLOGY
77	immune thrombocytopenia	AVATROMBOPAG\|FOSTAMATINIB	CLINICAL HAEMATOLOGY
78	influenza	AMANTADINE\|ZANAMIVIR\|BALOXAVIR	INFECTIOUS DISEASES
79	insomnia	ZALEPLON	NEUROLOGY
80	irritable bowel syndrome	ELUXADOLINE	GASTROENTEROLOGY
81	ischaemic stroke	ALTEPLASE	STROKE MEDICINE
82	juvenile idiopathic arthritis	ABATECEPT\|CANAKINUMAB\|TOCILIZUMAB\|TOFACITINIB	RHEUMATOLOGY
83	kidney transplant	BASILIXIMAB	NEPHROLOGY
84	leukaemia	FLUDARABINE\|IMATINIB	CLINICAL HAEMATOLOGY
85	lung cancer	ATEZOLIZUMAB\|DURVALUMAB\|GEFITINIB\|ORAL\|NINTEDANIB	MEDICAL ONCOLOGY
86	lymphoma	BENDAMUSTINE\|CRIZOTINIB\|PIXANTRONE\|RITUXIMAB	CLINICAL HAEMATOLOGY
87	macular degeneration	AFLIBERCEPT\|BROLUCIZUMAB\|FARICIMAB\|RANIBIZUMAB	OPHTHALMOLOGY
88	macular oedema	AFLIBERCEPT\|RANIBIZUMAB	OPHTHALMOLOGY
89	major depressive episodes	AGOMELATINE\|VORTIOXETINE	MENTAL HEALTH
90	malignant melanoma	VEMURAFENIB	MEDICAL ONCOLOGY
91	malignant pleural mesothelioma	NIVOLUMAB\|PEMETREXED	MEDICAL ONCOLOGY
92	manic episode	ARIPIPRAZOLE	MENTAL HEALTH
93	mantle cell lymphoma	AUTOLOGOUS\|BORTEZOMIB\|IBRUTINIB\|LENALIDOMIDE\|TEMSIROLIMUS	CLINICAL HAEMATOLOGY
94	melanoma	COBIMETINIB\|DABRAFENIB\|ENCORAFENIB\|IPILIMUMAB\|NIVOLUMAB\|PEMBROLIZUMAB\|TALIMOGENE\|TRAMETINIB	MEDICAL ONCOLOGY
95	merkel cell carcinoma	AVELUMAB	MEDICAL ONCOLOGY
96	migraine	BOTULINUM\|EPTINEZUMAB\|ERENUMAB\|FREMANEZUMAB\|GALCANEZUMAB	NEUROLOGY
97	motor neurone disease	RILUZOLE	NEUROLOGY
98	multiple myeloma	BORTEZOMIB\|THALIDOMIDE\|CARFILZOMIB\|DARATUMUMAB\|DENOSUMAB\|ELOTUZUMAB\|ISATUXIMAB\|IXAZOMIB\|LENALIDOMIDE\|PANOBINOSTAT\|POMALIDOMIDE\|SELINEXOR\|TECLISTAMAB	CLINICAL HAEMATOLOGY
99	multiple sclerosis	ALEMTUZUMAB\|BETA\|CLADRIBINE\|DACLIZUMAB\|DIMETHYL\|DIROXIMEL\|FINGOLIMOD\|INTERFERON\|NATALIZUMAB\|OCRELIZUMAB\|OZANIMOD\|PEGINTERFERON\|PONESIMOD\|SIPONIMOD\|TERIFLUNOMIDE	NEUROLOGY
100	myelodysplastic	LENALIDOMIDE\|LUSPATERCEPT	CLINICAL HAEMATOLOGY
101	myelofibrosis	FEDRATINIB\|RUXOLITINIB	CLINICAL HAEMATOLOGY
102	myocardial infarction	ALTEPLASE\|BIVALIRUDIN\|TICAGRELOR	CARDIOLOGY
103	myotonia	MEXILETINE	NEUROLOGY
104	narcolepsy	SOLRIAMFETOL	NEUROLOGY
105	neuroendocrine tumour	EVEROLIMUS\|LUTETIUM	MEDICAL ONCOLOGY
106	non-small cell lung cancer	ATEZOLIZMAB\|DOCETAXEL\|ERLOTINIB\|PEMETREXED	MEDICAL ONCOLOGY
107	non-small-cell lung cancer	AFATINIB\|ALECTINIB\|AMIVANTAMAB\|ATEZOLIZUMAB\|BEVACIZUMAB\|BRIGATINIB\|CEMIPLIMAB\|CERITINIB\|CRIZOTINIB\|DABRAFENIB\|DACOMITINIB\|DURVALUMAB\|ENTRECTINIB\|ERLOTINIB\|GEFITINIB\|LORLATINIB\|MOBOCERTINIB\|NECITUMUMAB\|NIVOLUMAB\|OSIMERTINIB\|PACLITAXEL\|PEMBROLIZUMAB\|PEMETREXED\|PRALSETINIB\|RAMUCIRUMAB\|SELPERCATINIB\|SOTORASIB\|TEPOTINIB	MEDICAL ONCOLOGY
108	obesity	LIRAGLUTIDE\|NALTREXONE\|ORLISTAT\|SEMAGLUTIDE\|SIBUTRAMINE	ENDOCRINOLOGY
109	oesophageal cancer	NIVOLUMAB	MEDICAL ONCOLOGY
110	osteoarthritis	CELECOXIB	RHEUMATOLOGY
111	osteoporosis	ALENDRONATE\|DENOSUMAB\|ORAL\|ROMOSOZUMAB	RHEUMATOLOGY
112	osteosarcoma	MIFAMURTIDE	MEDICAL ONCOLOGY
113	ovarian cancer	BEVACIZUMAB\|PACLITAXEL\|PEGYLATED\|TOPOTECAN\|TRABECTEDIN	MEDICAL ONCOLOGY
114	overweight	RIMONABANT	ENDOCRINOLOGY
115	pancreatic cancer	GEMCITABINE\|OLAPARIB\|PACLITAXEL\|PEGYLATED	MEDICAL ONCOLOGY
116	paroxysmal nocturnal haemoglobinuria	PEGCETACOPLAN\|RAVULIZUMAB	CLINICAL HAEMATOLOGY
117	peripheral arterial disease	NAFTIDROFYRYL	VASCULAR SURGERY
118	plaque psoriasis	ADALIMUMAB\|APREMILAST\|BIMEKIZUMAB\|BRODALUMAB\|CERTOLIZUMAB\|GUSELKUMAB\|INFLIXIMAB\|IXEKIZUMAB\|RISANKIZUMAB\|SECUKINUMAB\|TILDRAKIZUAMB\|USTEKINUMAB	DERMATOLOGY
119	polycystic kidney disease	TOLVAPTAN	NEPHROLOGY
120	polycythaemia vera	RUXOLITINIB	CLINICAL HAEMATOLOGY
121	pregnancy	ROUTINE	OBSTETRICS
122	primary biliary cholangitis	OBETICHOLIC	GASTROENTEROLOGY
123	primary hypercholesterolaemia	ALIROCUMAB\|EVOLOCUMAB	CARDIOLOGY
124	prostate cancer	ABIRATERONE\|APALUTAMIDE\|CABAZITAXEL\|DAROLUTAMIDE\|DEGARELIX\|DENOSUMAB\|DOCETAXEL\|ENZALUTAMIDE\|OLAPARIB\|PADELIPORFIN\|RADIUM-\|RADIUM\|SIPULEUCEL-T	MEDICAL ONCOLOGY
125	psoriasis	EFALUZIMAB	DERMATOLOGY
126	psoriatic arthritis	ABATACEPT\|ADALIMUMAB\|APREMILAST\|CERTOLIZUMAB\|ETANERCEPT\|GOLIMUMAB\|GUSELKUMAB\|IXEKIZUMAB\|RISANKIZUMAB\|TOFACITINIB\|UPADACITINIB\|USTEKINUMAB	RHEUMATOLOGY
127	pulmonary embolism	APIXABAN\|DABIGATRAN\|EDOXABAN\|RIVAROXABAN	THORACIC MEDICINE
128	pulmonary fibrosis	NINTEDANIB\|PIRFENIDONE	THORACIC MEDICINE
129	relapsing multiple sclerosis	OFATUMUMAB	NEUROLOGY
130	renal cell carcinoma	AVELUMAB\|AXITINIB\|BEVACIZUMAB\|CABOZANTINIB\|EVEROLIMUS\|LENVATINIB\|NIVOLUMAB\|PAZOPANIB\|PEMBROLIZUMAB\|SUNITINIB\|TIVOZANIB	MEDICAL ONCOLOGY
131	renal transplantation	BASILIXIMAB\|INDUCTION	NEPHROLOGY
132	retinal vein occlusion	AFLIBERCEPT\|DEXAMETHASONE\|RANIBIZUMAB	OPHTHALMOLOGY
133	rheumatoid arthritis	ABATACEPT\|ADALIMUMAB\|ANAKINRA\|BARICITINIB\|CELECOXIB\|CERTOLIZUMAB\|ETANERCEPT\|FILGOTINIB\|GOLIMUMAB\|RITUXIMAB\|SARILUMAB\|TOCILIZUMAB\|TOFACITINIB\|UPADACITINIB	RHEUMATOLOGY
134	rivaroxaban	ANDEXANET	CARDIOLOGY
135	schizophrenia	AMISULPRIDE\|ARIPIPRAZOLE\|LOXAPINE	MENTAL HEALTH
136	seizures	CANNABIDIOL	NEUROLOGY
137	sepsis	DROTRECOGIN	INFECTIOUS DISEASES
138	severe persistent allergic asthma	OMALIZUMAB	THORACIC MEDICINE
139	short bowel syndrome	TEDUGLUTIDE	GASTROENTEROLOGY
140	sickle cell disease	CRIZANLIZUMAB	CLINICAL HAEMATOLOGY
141	sleep apnoea	PITOLISANT\|SOLRIAMFETOL	THORACIC MEDICINE
142	smoking cessation	NICOTINE\|VARENICLINE	THORACIC MEDICINE
143	soft tissue sarcoma	INTRAVENOUS\|NBTXR-\|OLARATUMAB	MEDICAL ONCOLOGY
144	spinal muscular atrophy	NUSINERSEN\|RISDIPLAM	NEUROLOGY
145	squamous cell	CETUXIMAB	MEDICAL ONCOLOGY
146	squamous cell carcinoma	CEMIPLIMAB\|NIVOLUMAB\|PEMBROLIZUMAB	MEDICAL ONCOLOGY
147	stem cell transplant	MELPHALAN\|TREOSULFAN	CLINICAL HAEMATOLOGY
148	stroke	APIXABAN\|DABIGATRAN\|EDOXABAN\|RIVAROXABAN	STROKE MEDICINE
149	systemic lupus erythematosus	ANIFROLUMAB\|ETANERCEPT	RHEUMATOLOGY
150	systemic mastocytosis	MIDOSTAURIN	CLINICAL HAEMATOLOGY
151	thrombocytopenic purpura	ELTROMBOPAG\|ROMIPLOSTIM	CLINICAL HAEMATOLOGY
152	thrombotic thrombocytopenic purpura	CAPLACIZUMAB	CLINICAL HAEMATOLOGY
153	thyroid cancer	CABOZANTINIB\|LENVATINIB\|SELPERCATINIB\|VANDETANIB	MEDICAL ONCOLOGY
154	tophaceous gout	PEGLOTICASE	RHEUMATOLOGY
155	transitional cell carcinoma	VINFLUNINE	MEDICAL ONCOLOGY
156	tuberous sclerosis	CANNABIDIOL	NEUROLOGY
157	type 1 diabetes	CONTINUOUS\|DAPAGLIFLOZIN\|INSULIN\|SOTAGLIFLOZIN	DIABETIC MEDICINE
158	type 2 diabetes	CANAGLIFLOZIN\|CONTINUOUS\|DAPAGLIFLOZIN\|EMPAGLIFLOZIN\|ERTUGLIFLOZIN\|EXENATIDE\|FINERENONE\|INSULIN\|LIRAGLUTIDE\|PIOGLITAZONE\|ROSIGLITAZONE	DIABETIC MEDICINE
159	ulcerative colitis	ADALIMUMAB\|INFLIXIMAB\|FILGOTINIB\|OZANIMOD\|TOFACITINIB\|UPADACITINIB\|USTEKINUMAB\|VEDOLIZUMAB	GASTROENTEROLOGY
160	urothelial carcinoma	ATEZOLIZUMAB\|PEMBROLIZUMAB	MEDICAL ONCOLOGY
161	urticaria	OMALIZUMAB	DERMATOLOGY
162	uterine fibroids	RELUGOLIX	GYNAECOLOGY
163	uveitis	ADALIMUMAB\|FLUOCINOLONE	OPHTHALMOLOGY
164	vascular disease	MODIFIED-RELEASE\|CLOPIDOGREL	VASCULAR SURGERY
165	vasculitis	RITUXIMAB	RHEUMATOLOGY
166	venous thromboembolism	APIXABAN\|DABIGATRAN\|RIVAROXABAN	CLINICAL HAEMATOLOGY

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