feat: complete drug-aware indication matching and cleanup app_v2
- Remove app_v2.py (consolidated into pathways_app.py), fix __init__ import - Add DimSearchTerm.csv, drug_indication_clusters.csv, drug_snomed_mapping_enriched.csv as reference data for SNOMED-based indication matching - Add snomed_indication_mapping_query.sql (source for embedded cluster mapping) - Update DESIGN_SYSTEM.md, RALPH_PROMPT.md, ralph.ps1, uv.lock
This commit is contained in:
Andrew Charlwood
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Drug,Indication,Cluster_ID,Cluster_Description,NICE_TA_Reference
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ABATACEPT,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA195/TA280/TA375
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ABATACEPT,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA195/TA280/TA375
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ABATACEPT,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA568
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ACALABRUTINIB,Chronic lymphocytic leukaemia,CLL_COD,Chronic lymphocytic leukaemia,TA689
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ADALIMUMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA130/TA195/TA375
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ADALIMUMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA130/TA195/TA375
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ADALIMUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA146/TA455
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ADALIMUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA146/TA455
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ADALIMUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA125/TA199
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ADALIMUMAB,Crohn's disease,CROHNS_COD,Crohn's disease codes,TA187
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ADALIMUMAB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA329
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ADALIMUMAB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA143/TA383
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AFLIBERCEPT,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA346
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AFLIBERCEPT,Diabetic macular oedema,DMTYPE2AUDIT_COD,Type 2 diabetes codes,TA346
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ALIROCUMAB,Hypercholesterolaemia,HYPERCHOL_COD,Hypercholesterolaemia codes,TA393
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APREMILAST,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA419
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APREMILAST,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA419
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APREMILAST,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA433
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ATEZOLIZUMAB,Cancer (various),CANCER_COD,Cancer codes (various),TA492/TA520/TA525
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BARICITINIB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA466
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BARICITINIB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA466
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BARICITINIB,Atopic dermatitis,ECZEMA_COD,Atopic dermatitis/eczema codes,TA681
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BEVACIZUMAB,Cancer (various),CANCER_COD,Cancer codes (various),TA584/TA666
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BIMEKIZUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA723
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BIMEKIZUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA723
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BOTULINUM A TOXIN,Spasticity (various),SPASTICITY_COD,Spasticity and movement disorder codes,No specific TA
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BRODALUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA511
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BRODALUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA511
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CERTOLIZUMAB PEGOL,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA375/TA415
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CERTOLIZUMAB PEGOL,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA375/TA415
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CERTOLIZUMAB PEGOL,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA574
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CERTOLIZUMAB PEGOL,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA445
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CERTOLIZUMAB PEGOL,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA383
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DENOSUMAB,Osteoporosis,OSTEO_COD,Osteoporosis codes,TA204
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DENOSUMAB,Bone metastases,CANCER_COD,Cancer codes (bone metastases),TA265
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DEXAMETHASONE,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA349/TA824
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DEXAMETHASONE,Diabetic macular oedema,DMTYPE2AUDIT_COD,Type 2 diabetes codes,TA349/TA824
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DEXAMETHASONE,Multiple myeloma,MM_COD,Multiple myeloma codes,TA311/TA380
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DEXAMETHASONE,Uveitis,UVEITIS_COD,Uveitis codes,TA460
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DIMETHYL FUMARATE,Multiple sclerosis,MS_COD,Multiple sclerosis codes,TA320
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DIMETHYL FUMARATE,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA475
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DOCETAXEL,Cancer (various),CANCER_COD,Cancer codes (breast/lung/prostate),TA006/TA030/TA101
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DUPILUMAB,Atopic dermatitis,ECZEMA_COD,Atopic dermatitis/eczema codes,TA534
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DUPILUMAB,Asthma,ASTHMA_COD,Asthma codes,TA751
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ERENUMAB,Migraine,MIGRAINE_COD,Migraine codes,TA682
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ETANERCEPT,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA036/TA130/TA195
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ETANERCEPT,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA036/TA130/TA195
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ETANERCEPT,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA103
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ETANERCEPT,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA103
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ETANERCEPT,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA104/TA199
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ETANERCEPT,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA143/TA383
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EVOLOCUMAB,Hypercholesterolaemia,HYPERCHOL_COD,Hypercholesterolaemia codes,TA394
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FARICIMAB,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA799
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FARICIMAB,Diabetic macular oedema,DMTYPE2AUDIT_COD,Type 2 diabetes codes,TA799
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FILGOTINIB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA676
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FILGOTINIB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA676
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FILGOTINIB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA792
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FLUOCINOLONE,Atopic dermatitis,ECZEMA_COD,Atopic dermatitis/eczema codes,TA081
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FLUOCINOLONE,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA301
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FLUOCINOLONE,Uveitis,UVEITIS_COD,Uveitis codes,TA590
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FLUOCINOLONE ACETONIDE,Atopic dermatitis,ECZEMA_COD,Atopic dermatitis/eczema codes,TA081
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FLUOCINOLONE ACETONIDE,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA301
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FLUOCINOLONE ACETONIDE,Uveitis,UVEITIS_COD,Uveitis codes,TA590
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FREMANEZUMAB,Migraine,MIGRAINE_COD,Migraine codes,TA631/TA764
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GALCANEZUMAB,Migraine,MIGRAINE_COD,Migraine codes,TA659
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GOLIMUMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA225/TA375
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GOLIMUMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA225/TA375
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GOLIMUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA220
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GOLIMUMAB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA329
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GOLIMUMAB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA233/TA383
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GUSELKUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA521
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GUSELKUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA521
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GUSELKUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA711/TA815
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IDARUCIZUMAB,Anticoagulant reversal,ANTICOAG_COD,Anticoagulation-related codes,No specific TA
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IMATINIB,Chronic myeloid leukaemia,CML_COD,Chronic myeloid leukaemia codes,TA050/TA070/TA251
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IMATINIB,Gastrointestinal stromal tumours,GIST_COD,Gastrointestinal stromal tumour codes,TA086/TA326
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IMMUNOGLOBULIN,Immunodeficiency (various),IMMUNODEF_COD,Primary/secondary immunodeficiency codes,TA481/TA482
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INFLIXIMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA036/TA130/TA195
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INFLIXIMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA036/TA130/TA195
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INFLIXIMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA134
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INFLIXIMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA134
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INFLIXIMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA104/TA199
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INFLIXIMAB,Crohn's disease,CROHNS_COD,Crohn's disease codes,TA040/TA187
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INFLIXIMAB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA163/TA329
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INFLIXIMAB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA383
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IXEKIZUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA442
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IXEKIZUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA442
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IXEKIZUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA537
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IXEKIZUMAB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA718
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LUCENTIS,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,Biosimilar of ranibizumab
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LUCENTIS,Diabetic macular oedema,DMTYPE2AUDIT_COD,Type 2 diabetes codes,Biosimilar of ranibizumab
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OBINUTUZUMAB,Chronic lymphocytic leukaemia,CLL_COD,Chronic lymphocytic leukaemia codes,TA343/TA663
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OBINUTUZUMAB,Follicular lymphoma,FL_COD,Follicular lymphoma codes,TA472/TA513/TA629
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OCTREOTIDE,Neuroendocrine tumours,NET_COD,Neuroendocrine tumour codes,No specific TA
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OMALIZUMAB,Asthma,ASTHMA_COD,Asthma codes,TA133/TA278
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OMALIZUMAB,Chronic urticaria,URTICARIA_COD,Urticaria codes,TA339
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RANIBIZUMAB,Diabetic macular oedema,DM_COD,Diabetes mellitus codes,TA274
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RANIBIZUMAB,Diabetic macular oedema,DMTYPE2AUDIT_COD,Type 2 diabetes codes,TA274
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REMICADE,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,Brand name for infliximab
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REMICADE,Crohn's disease,CROHNS_COD,Crohn's disease codes,Brand name for infliximab
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REMICADE,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,Brand name for infliximab
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REMICADE,Psoriasis,PSORIASIS_COD,Psoriasis codes,Brand name for infliximab
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RILUZOLE,Motor neurone disease,MND_COD,Motor neurone disease codes,TA020
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RISANKIZUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA596
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RISANKIZUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA596
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RISANKIZUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA803
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RITUXIMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA126/TA195
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RITUXIMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA126/TA195
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RITUXIMAB,Non-Hodgkin's lymphoma,NHL_COD,Non-Hodgkin's lymphoma codes,TA037/TA065/TA110
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RITUXIMAB,Chronic lymphocytic leukaemia,CLL_COD,Chronic lymphocytic leukaemia codes,TA174/TA193/TA359
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RITUXIMAB,ANCA-associated vasculitis,VASCULITIS_COD,Vasculitis codes,TA308
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RIXATHON,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,Biosimilar of rituximab
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RIXATHON,Non-Hodgkin's lymphoma,NHL_COD,Non-Hodgkin's lymphoma codes,Biosimilar of rituximab
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SACITUZUMAB,Triple-negative breast cancer,BREASTCA_COD,Breast cancer codes,TA819
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SARILUMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA485
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SARILUMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA485
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SECUKINUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA350/TA734
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SECUKINUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA350/TA734
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SECUKINUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA445
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SECUKINUMAB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA407/TA719
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TERIPARATIDE,Osteoporosis,OSTEO_COD,Osteoporosis codes,TA087/TA161
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TILDRAKIZUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,No TA match found
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TILDRAKIZUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),No TA match found
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TOCILIZUMAB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA198/TA247/TA375
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TOCILIZUMAB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA198/TA247/TA375
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TOCILIZUMAB,Juvenile idiopathic arthritis,JIA_COD,Juvenile idiopathic arthritis codes,TA238/TA373
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TOCILIZUMAB,Giant cell arteritis,GCA_COD,Giant cell arteritis codes,TA518
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TOFACITINIB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA480
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TOFACITINIB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA480
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TOFACITINIB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA543
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TOFACITINIB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA547
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UPADACITINIB,Rheumatoid arthritis,RARTH_COD,Rheumatoid arthritis diagnosis codes,TA665/TA744
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UPADACITINIB,Rheumatoid arthritis,C19RARTH_COD,Rheumatoid arthritis disorders (broader),TA665/TA744
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UPADACITINIB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA768
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UPADACITINIB,Atopic dermatitis,ECZEMA_COD,Atopic dermatitis/eczema codes,TA814
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UPADACITINIB,Ankylosing spondylitis,ANKSPON_COD,Ankylosing spondylitis codes,TA829
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UPADACITINIB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA856
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USTEKINUMAB,Psoriasis,PSORIASIS_COD,Psoriasis codes,TA180/TA455
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USTEKINUMAB,Psoriasis,CUST_CMMS_PSORIASIS,Psoriasis (Cambridge Multimorbidity),TA180/TA455
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USTEKINUMAB,Psoriatic arthritis,PSORIASIS_COD,Psoriasis codes (for psoriatic arthritis),TA340
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USTEKINUMAB,Crohn's disease,CROHNS_COD,Crohn's disease codes,TA456
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USTEKINUMAB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA633
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VEDOLIZUMAB,Ulcerative colitis,ULCCOLITIS_COD,Ulcerative colitis codes,TA342
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VEDOLIZUMAB,Crohn's disease,CROHNS_COD,Crohn's disease codes,TA352
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