feat: complete drug-aware indication matching and cleanup app_v2
- Remove app_v2.py (consolidated into pathways_app.py), fix __init__ import - Add DimSearchTerm.csv, drug_indication_clusters.csv, drug_snomed_mapping_enriched.csv as reference data for SNOMED-based indication matching - Add snomed_indication_mapping_query.sql (source for embedded cluster mapping) - Update DESIGN_SYSTEM.md, RALPH_PROMPT.md, ralph.ps1, uv.lock
This commit is contained in:
Andrew Charlwood
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Search_Term,CleanedDrugName,PrimaryDirectorate
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acute coronary syndrome,ABCIXIMAB|CLOPIDOGREL|PRASUGREL|RIVAROXABAN|TICAGRELOR,CARDIOLOGY
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acute lymphoblastic leukaemia,BLINATUMOMAB|DASATINIB|INOTUZUMAB|PEGASPARGASE|PONATINIB|TISAGENLECLEUCEL,CLINICAL HAEMATOLOGY
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acute myeloid leukaemia,AZACITIDINE|DECITABINE|GEMTUZUMAB|GILTERITINIB|GLASDEGIB|LIPOSOMAL|MIDOSTAURIN|ORAL|VENETOCLAX,CLINICAL HAEMATOLOGY
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acute promyelocytic leukaemia,ARSENIC|GEMTUZUMAB,CLINICAL HAEMATOLOGY
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allergic asthma,OMALIZUMAB,THORACIC MEDICINE
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allergic rhinitis,SQ,ENT
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alzheimer's disease,DONEPEZIL,NEUROLOGY
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amyloidosis,VUTRISIRAN,CLINICAL HAEMATOLOGY
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anaemia,ERYTHROPOIESIS-STIMULATING|ERYTHROPOIETIN,CLINICAL HAEMATOLOGY
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anaplastic large cell lymphoma,BRENTUXIMAB,CLINICAL HAEMATOLOGY
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ankylosing spondylitis,ADALIMUMAB|GOLIMUMAB|SECUKINUMAB|UPADACITINIB,RHEUMATOLOGY
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apixaban,ANDEXANET,CARDIOLOGY
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aplastic anaemia,ELTROMBOPAG,CLINICAL HAEMATOLOGY
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arthritis,ETANERCEPT,RHEUMATOLOGY
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asthma,BENRALIZUMAB|DUPILUMAB|INHALED|MEPOLIZUMAB|OMALIZUMAB|RESLIZUMAB,THORACIC MEDICINE
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atopic dermatitis,ABROCITINIB|ALCLOMETASONE|BARICITINIB|CRISABOROLE|DUPILUMAB|PIMECROLIMUS,DERMATOLOGY
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atrial fibrillation,APIXABAN|DABIGATRAN|DRONEDARONE|EDOXABAN|RIVAROXABAN|VERNAKALANT,CARDIOLOGY
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attention deficit hyperactivity disorder,ATOMOXETINE,MENTAL HEALTH
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attention-deficit hyperactivity disorder,METHYLPHENIDATE,MENTAL HEALTH
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axial spondyloarthritis,ADALIMUMAB|GOLIMUMAB|IXEKIZUMAB|SECUKINUMAB|UPADACITINIB,RHEUMATOLOGY
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basal cell carcinoma,VISMODEGIB,DERMATOLOGY
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bipolar disorder,LOXAPINE|OLANZAPINE,MENTAL HEALTH
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bladder,MIRABEGRON,MEDICAL ONCOLOGY
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brca,OLAPARIB,MEDICAL ONCOLOGY
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breast cancer,ABEMACICLIB|ALPELISIB|ANASTROZOLE|ATEZOLIZUMAB|BEVACIZUMAB|CAPECITABINE|DENOSUMAB|DOCETAXEL|ERIBULIN|EVEROLIMUS|FULVESTRANT|GEMCITABINE|INTRABEAM|LAPATINIB|NERATINIB|OLAPARIB|PACLITAXEL|PALBOCICLI|PALBOCICLIB|PEMBROLIZUMAB|PERTUZUMAB|RIBOCICLIB|SACITUZUMAB|TRASTUZUMAB|TUCATINIB|VINORELBINE,MEDICAL ONCOLOGY
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cardiomyopathy,TAFAMIDIS,CARDIOLOGY
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cardiovascular disease,ATORVASTATIN,CARDIOLOGY
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cervical cancer,TOPOTECAN,MEDICAL ONCOLOGY
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cholangiocarcinoma,PEMIGATINIB,MEDICAL ONCOLOGY
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choroidal neovascularisation,AFLIBERCEPT|RANIBIZUMAB,OPHTHALMOLOGY
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chronic kidney disease,DAPAGLIFLOZIN|IMLIFIDASE|ROXADUSTAT,NEPHROLOGY
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chronic liver disease,AVATROMBOPAG|LUSUTROMBOPAG,GASTROENTEROLOGY
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chronic lymphocytic leukaemia,ACALABRUTINIB|BENDAMUSTINE|DUVELISIB|IBRUTINIB|IDELALISIB|OBINUTUZUMAB|OFATUMUMAB|RITUXIMAB|VENETOCLAX,CLINICAL HAEMATOLOGY
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chronic myeloid leukaemia,ASCIMINIB|BOSUTINIB|STANDARD-DOSE|DASATINIB|DASITINIB|NILOTINIB|PONATINIB,CLINICAL HAEMATOLOGY
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chronic obstructive pulmonary disease,ROFLUMILAST,THORACIC MEDICINE
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colon cancer,CAPECITABINE,MEDICAL ONCOLOGY
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colorectal cancer,BEVACIZUMAB|CAPECITABINE|IRINOTECAN,MEDICAL ONCOLOGY
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constipation,LUBIPROSTONE|METHYLNALTREXONE|NALDEMEDINE|NALOXEGOL|PRUCALOPRIDE,GASTROENTEROLOGY
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covid-19,NIRMATRELVIR,INFECTIOUS DISEASES
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crohn's disease,INFLIXIMAB|VEDOLIZUMAB,GASTROENTEROLOGY
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cutaneous t-cell lymphoma,BRENTUXIMAB|CHLORMETHINE,CLINICAL HAEMATOLOGY
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cystic fibrosis,COLISTIMETHATE|LUMACAFTOR|MANNITOL,THORACIC MEDICINE
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cytomegalovirus,LETERMOVIR|MARIBAVIR,INFECTIOUS DISEASES
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deep vein thrombosis,APIXABAN|DABIGATRAN|EDOXABAN|RIVAROXABAN,VASCULAR SURGERY
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depression,ESKETAMINE,MENTAL HEALTH
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diabetes,ERTUGLIFLOZIN|INHALED|AFLIBERCEPT|BROLUCIZUMAB|DEXAMETHASONE|FARICIMAB|FLUOCINOLONE|RANIBIZUMAB,DIABETIC MEDICINE
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diabetes,ERTUGLIFLOZIN|INHALED|AFLIBERCEPT|BROLUCIZUMAB|DEXAMETHASONE|FARICIMAB|FLUOCINOLONE|RANIBIZUMAB,OPHTHALMOLOGY
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diabetic retinopathy,RANIBUZIMAB,OPHTHALMOLOGY
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diffuse large b-cell lymphoma,AXICABTAGENE|POLATUZUMAB|TISAGENLECLEUCEL,CLINICAL HAEMATOLOGY
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dravet syndrome,CANNABIDIOL|FENFLURAMINE,NEUROLOGY
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drug misuse,BUPRENORPHINE|NALTREXONE,MENTAL HEALTH
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dry eye,CICLOSPORIN,OPHTHALMOLOGY
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dyspepsia,LANSOPRAZOLE,GASTROENTEROLOGY
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endometrial cancer,DOSTARLIMAB,MEDICAL ONCOLOGY
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epilepsy,CENOBAMATE|GABAPENTIN|RETIGABINE,NEUROLOGY
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fallopian tube,BEVACIZUMAB|NIRAPARIB|OLAPARIB|RUCAPARIB,MEDICAL ONCOLOGY
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follicular lymphoma,DUVELISIB|IDELALISIB|LENALIDOMIDE|OBINUTUZUMAB|RITUXIMAB|TISAGENLECLEUCEL,CLINICAL HAEMATOLOGY
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gastric cancer,CAPECITABINE|RAMUCIRUMAB|TRASTUZUMAB|TRIFLURIDINE,MEDICAL ONCOLOGY
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gastro-oesophageal junction,NIVOLUMAB|PEMBROLIZUMAB,MEDICAL ONCOLOGY
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giant cell arteritis,TOCILIZUMAB,RHEUMATOLOGY
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glioma,CARMUSTINE,MEDICAL ONCOLOGY
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gout,CANAKINUMAB|FEBUXOSTAT|LESINURAD,RHEUMATOLOGY
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graft versus host disease,RUXOLITINIB,CLINICAL HAEMATOLOGY
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granulomatosis with polyangiitis,AVACOPAN|MEPOLIZUMAB,RHEUMATOLOGY
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growth hormone deficiency,SOMATROPIN,ENDOCRINOLOGY
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hand eczema,ALITRETINOIN,DERMATOLOGY
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heart failure,DAPAGLIFLOZIN|EMPAGLIFLOZIN|IVABRADINE|SACUBITRIL|VERICIGUAT,CARDIOLOGY
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hepatitis b,ADEFOVIR,GASTROENTEROLOGY
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hepatitis c,BOCEPREVIR|DACLATASVIR|ELBASVIR|GLECAPREVIR|INTERFERON|LEDIPASVIR|OMBITASVIR|PEGINTERFERON|PEGYLATED|SIMEPREVIR|SOFOSBUVIR|TELAPREVIR,GASTROENTEROLOGY
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hepatocellular carcinoma,ATEZOLIZUMAB|CABOZANTINIB|LENVATINIB|RAMUCIRUMAB|REGORAFENIB|SELECTIVE|SORAFENIB,MEDICAL ONCOLOGY
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hiv,CABOTEGRAVIR,INFECTIOUS DISEASES
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hodgkin lymphoma,BRENTUXIMAB|NIVOLUMAB|PEMBROLIZUMAB,CLINICAL HAEMATOLOGY
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hormone receptor,ABEMACICLIB,MEDICAL ONCOLOGY
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hypercholesterolaemia,EZETIMIBE,CARDIOLOGY
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hyperparathyroidism,CINACALCET|ETELCALCETIDE,ENDOCRINOLOGY
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immune thrombocytopenia,AVATROMBOPAG|FOSTAMATINIB,CLINICAL HAEMATOLOGY
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influenza,AMANTADINE|ZANAMIVIR|BALOXAVIR,INFECTIOUS DISEASES
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insomnia,ZALEPLON,NEUROLOGY
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irritable bowel syndrome,ELUXADOLINE,GASTROENTEROLOGY
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ischaemic stroke,ALTEPLASE,STROKE MEDICINE
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juvenile idiopathic arthritis,ABATECEPT|CANAKINUMAB|TOCILIZUMAB|TOFACITINIB,RHEUMATOLOGY
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kidney transplant,BASILIXIMAB,NEPHROLOGY
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leukaemia,FLUDARABINE|IMATINIB,CLINICAL HAEMATOLOGY
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lung cancer,ATEZOLIZUMAB|DURVALUMAB|GEFITINIB|ORAL|NINTEDANIB,MEDICAL ONCOLOGY
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lymphoma,BENDAMUSTINE|CRIZOTINIB|PIXANTRONE|RITUXIMAB,CLINICAL HAEMATOLOGY
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macular degeneration,AFLIBERCEPT|BROLUCIZUMAB|FARICIMAB|RANIBIZUMAB,OPHTHALMOLOGY
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macular oedema,AFLIBERCEPT|RANIBIZUMAB,OPHTHALMOLOGY
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major depressive episodes,AGOMELATINE|VORTIOXETINE,MENTAL HEALTH
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malignant melanoma,VEMURAFENIB,MEDICAL ONCOLOGY
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malignant pleural mesothelioma,NIVOLUMAB|PEMETREXED,MEDICAL ONCOLOGY
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manic episode,ARIPIPRAZOLE,MENTAL HEALTH
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mantle cell lymphoma,AUTOLOGOUS|BORTEZOMIB|IBRUTINIB|LENALIDOMIDE|TEMSIROLIMUS,CLINICAL HAEMATOLOGY
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melanoma,COBIMETINIB|DABRAFENIB|ENCORAFENIB|IPILIMUMAB|NIVOLUMAB|PEMBROLIZUMAB|TALIMOGENE|TRAMETINIB,MEDICAL ONCOLOGY
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merkel cell carcinoma,AVELUMAB,MEDICAL ONCOLOGY
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migraine,BOTULINUM|EPTINEZUMAB|ERENUMAB|FREMANEZUMAB|GALCANEZUMAB,NEUROLOGY
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motor neurone disease,RILUZOLE,NEUROLOGY
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multiple myeloma,BORTEZOMIB|THALIDOMIDE|CARFILZOMIB|DARATUMUMAB|DENOSUMAB|ELOTUZUMAB|ISATUXIMAB|IXAZOMIB|LENALIDOMIDE|PANOBINOSTAT|POMALIDOMIDE|SELINEXOR|TECLISTAMAB,CLINICAL HAEMATOLOGY
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multiple sclerosis,ALEMTUZUMAB|BETA|CLADRIBINE|DACLIZUMAB|DIMETHYL|DIROXIMEL|FINGOLIMOD|INTERFERON|NATALIZUMAB|OCRELIZUMAB|OZANIMOD|PEGINTERFERON|PONESIMOD|SIPONIMOD|TERIFLUNOMIDE,NEUROLOGY
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myelodysplastic,LENALIDOMIDE|LUSPATERCEPT,CLINICAL HAEMATOLOGY
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myelofibrosis,FEDRATINIB|RUXOLITINIB,CLINICAL HAEMATOLOGY
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myocardial infarction,ALTEPLASE|BIVALIRUDIN|TICAGRELOR,CARDIOLOGY
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myotonia,MEXILETINE,NEUROLOGY
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narcolepsy,SOLRIAMFETOL,NEUROLOGY
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neuroendocrine tumour,EVEROLIMUS|LUTETIUM,MEDICAL ONCOLOGY
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non-small cell lung cancer,ATEZOLIZMAB|DOCETAXEL|ERLOTINIB|PEMETREXED,MEDICAL ONCOLOGY
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non-small-cell lung cancer,AFATINIB|ALECTINIB|AMIVANTAMAB|ATEZOLIZUMAB|BEVACIZUMAB|BRIGATINIB|CEMIPLIMAB|CERITINIB|CRIZOTINIB|DABRAFENIB|DACOMITINIB|DURVALUMAB|ENTRECTINIB|ERLOTINIB|GEFITINIB|LORLATINIB|MOBOCERTINIB|NECITUMUMAB|NIVOLUMAB|OSIMERTINIB|PACLITAXEL|PEMBROLIZUMAB|PEMETREXED|PRALSETINIB|RAMUCIRUMAB|SELPERCATINIB|SOTORASIB|TEPOTINIB,MEDICAL ONCOLOGY
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obesity,LIRAGLUTIDE|NALTREXONE|ORLISTAT|SEMAGLUTIDE|SIBUTRAMINE,ENDOCRINOLOGY
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oesophageal cancer,NIVOLUMAB,MEDICAL ONCOLOGY
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osteoarthritis,CELECOXIB,RHEUMATOLOGY
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osteoporosis,ALENDRONATE|DENOSUMAB|ORAL|ROMOSOZUMAB,RHEUMATOLOGY
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osteosarcoma,MIFAMURTIDE,MEDICAL ONCOLOGY
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ovarian cancer,BEVACIZUMAB|PACLITAXEL|PEGYLATED|TOPOTECAN|TRABECTEDIN,MEDICAL ONCOLOGY
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overweight,RIMONABANT,ENDOCRINOLOGY
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pancreatic cancer,GEMCITABINE|OLAPARIB|PACLITAXEL|PEGYLATED,MEDICAL ONCOLOGY
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paroxysmal nocturnal haemoglobinuria,PEGCETACOPLAN|RAVULIZUMAB,CLINICAL HAEMATOLOGY
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peripheral arterial disease,NAFTIDROFYRYL,VASCULAR SURGERY
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plaque psoriasis,ADALIMUMAB|APREMILAST|BIMEKIZUMAB|BRODALUMAB|CERTOLIZUMAB|GUSELKUMAB|INFLIXIMAB|IXEKIZUMAB|RISANKIZUMAB|SECUKINUMAB|TILDRAKIZUAMB|USTEKINUMAB,DERMATOLOGY
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polycystic kidney disease,TOLVAPTAN,NEPHROLOGY
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polycythaemia vera,RUXOLITINIB,CLINICAL HAEMATOLOGY
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pregnancy,ROUTINE,OBSTETRICS
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primary biliary cholangitis,OBETICHOLIC,GASTROENTEROLOGY
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primary hypercholesterolaemia,ALIROCUMAB|EVOLOCUMAB,CARDIOLOGY
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prostate cancer,ABIRATERONE|APALUTAMIDE|CABAZITAXEL|DAROLUTAMIDE|DEGARELIX|DENOSUMAB|DOCETAXEL|ENZALUTAMIDE|OLAPARIB|PADELIPORFIN|RADIUM-|RADIUM|SIPULEUCEL-T,MEDICAL ONCOLOGY
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psoriasis,EFALUZIMAB,DERMATOLOGY
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psoriatic arthritis,ABATACEPT|ADALIMUMAB|APREMILAST|CERTOLIZUMAB|ETANERCEPT|GOLIMUMAB|GUSELKUMAB|IXEKIZUMAB|RISANKIZUMAB|TOFACITINIB|UPADACITINIB|USTEKINUMAB,RHEUMATOLOGY
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pulmonary embolism,APIXABAN|DABIGATRAN|EDOXABAN|RIVAROXABAN,THORACIC MEDICINE
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pulmonary fibrosis,NINTEDANIB|PIRFENIDONE,THORACIC MEDICINE
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relapsing multiple sclerosis,OFATUMUMAB,NEUROLOGY
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renal cell carcinoma,AVELUMAB|AXITINIB|BEVACIZUMAB|CABOZANTINIB|EVEROLIMUS|LENVATINIB|NIVOLUMAB|PAZOPANIB|PEMBROLIZUMAB|SUNITINIB|TIVOZANIB,MEDICAL ONCOLOGY
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renal transplantation,BASILIXIMAB|INDUCTION,NEPHROLOGY
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retinal vein occlusion,AFLIBERCEPT|DEXAMETHASONE|RANIBIZUMAB,OPHTHALMOLOGY
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rheumatoid arthritis,ABATACEPT|ADALIMUMAB|ANAKINRA|BARICITINIB|CELECOXIB|CERTOLIZUMAB|ETANERCEPT|FILGOTINIB|GOLIMUMAB|RITUXIMAB|SARILUMAB|TOCILIZUMAB|TOFACITINIB|UPADACITINIB,RHEUMATOLOGY
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rivaroxaban,ANDEXANET,CARDIOLOGY
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schizophrenia,AMISULPRIDE|ARIPIPRAZOLE|LOXAPINE,MENTAL HEALTH
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seizures,CANNABIDIOL,NEUROLOGY
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sepsis,DROTRECOGIN,INFECTIOUS DISEASES
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severe persistent allergic asthma,OMALIZUMAB,THORACIC MEDICINE
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short bowel syndrome,TEDUGLUTIDE,GASTROENTEROLOGY
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sickle cell disease,CRIZANLIZUMAB,CLINICAL HAEMATOLOGY
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sleep apnoea,PITOLISANT|SOLRIAMFETOL,THORACIC MEDICINE
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smoking cessation,NICOTINE|VARENICLINE,THORACIC MEDICINE
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soft tissue sarcoma,INTRAVENOUS|NBTXR-|OLARATUMAB,MEDICAL ONCOLOGY
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spinal muscular atrophy,NUSINERSEN|RISDIPLAM,NEUROLOGY
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squamous cell,CETUXIMAB,MEDICAL ONCOLOGY
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squamous cell carcinoma,CEMIPLIMAB|NIVOLUMAB|PEMBROLIZUMAB,MEDICAL ONCOLOGY
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stem cell transplant,MELPHALAN|TREOSULFAN,CLINICAL HAEMATOLOGY
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stroke,APIXABAN|DABIGATRAN|EDOXABAN|RIVAROXABAN,STROKE MEDICINE
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systemic lupus erythematosus,ANIFROLUMAB|ETANERCEPT,RHEUMATOLOGY
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systemic mastocytosis,MIDOSTAURIN,CLINICAL HAEMATOLOGY
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thrombocytopenic purpura,ELTROMBOPAG|ROMIPLOSTIM,CLINICAL HAEMATOLOGY
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thrombotic thrombocytopenic purpura,CAPLACIZUMAB,CLINICAL HAEMATOLOGY
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thyroid cancer,CABOZANTINIB|LENVATINIB|SELPERCATINIB|VANDETANIB,MEDICAL ONCOLOGY
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tophaceous gout,PEGLOTICASE,RHEUMATOLOGY
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transitional cell carcinoma,VINFLUNINE,MEDICAL ONCOLOGY
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tuberous sclerosis,CANNABIDIOL,NEUROLOGY
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type 1 diabetes,CONTINUOUS|DAPAGLIFLOZIN|INSULIN|SOTAGLIFLOZIN,DIABETIC MEDICINE
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type 2 diabetes,CANAGLIFLOZIN|CONTINUOUS|DAPAGLIFLOZIN|EMPAGLIFLOZIN|ERTUGLIFLOZIN|EXENATIDE|FINERENONE|INSULIN|LIRAGLUTIDE|PIOGLITAZONE|ROSIGLITAZONE,DIABETIC MEDICINE
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ulcerative colitis,ADALIMUMAB|INFLIXIMAB|FILGOTINIB|OZANIMOD|TOFACITINIB|UPADACITINIB|USTEKINUMAB|VEDOLIZUMAB,GASTROENTEROLOGY
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urothelial carcinoma,ATEZOLIZUMAB|PEMBROLIZUMAB,MEDICAL ONCOLOGY
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urticaria,OMALIZUMAB,DERMATOLOGY
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uterine fibroids,RELUGOLIX,GYNAECOLOGY
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uveitis,ADALIMUMAB|FLUOCINOLONE,OPHTHALMOLOGY
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vascular disease,MODIFIED-RELEASE|CLOPIDOGREL,VASCULAR SURGERY
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vasculitis,RITUXIMAB,RHEUMATOLOGY
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venous thromboembolism,APIXABAN|DABIGATRAN|RIVAROXABAN,CLINICAL HAEMATOLOGY
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